/ Home
/ SUBMISSION

/ The BJOC
/ Diamond Open Access
/ Journal Statistics
/ Editorial Board
/ Community
/ Call for papers

/ Latest Articles
/ Most accessed
/ Thematic issues
/ Volumes
/ Authors

/ Alerts

/ TWITTER
/ LINKEDIN
/ Mastodon
/ RSS FEED

Empty search

Article Type

Publication Date Range

Search Tips

This search combines search strings from the content search (i.e. "Full Text", "Author", "Title", "Abstract", or "Keywords") with "Article Type" and "Publication Date Range" using the AND operator.

Search Examples

aromatic	the word “aromatic”
aromatic aldehyde	the word “aromatic” OR “aldehyde”
+aromatic +aldehyde	both words “aromatic” AND “aldehyde”
+aromatic -aldehyde	the word “aromatic” but NOT “aldehyde”
“aromatic aldehyde”	the exact phrase “aromatic aldehyde”
benz*	words which begin with “benz”, such as “benzene” or “benzyl”
benz*yl	words that begin with “benz” and end with “yl”, such as “benzyl” or “benzoyl”
benzyl~	words that are close to the word “benzyl”, such as “benzoyl” (i.e., fuzzy search)

BROWSE
Latest Articles
Most accessed
thematic issues
volumes
authors

BROWSE

Latest Articles Most Accessed Thematic Issues Volumes Authors

Author

2 article(s) from Gettys, Kristen E

Decarboxylative and dehydrative coupling of dienoic acids and pentadienyl alcohols to form 1,3,6,8-tetraenes

Ghina’a I. Abu Deiab,
Mohammed H. Al-Huniti,
I. F. Dempsey Hyatt,
Emma E. Nagy,
Kristen E. Gettys,
Sommayah S. Sayed,
Christine M. Joliat,
Paige E. Daniel,
Rupa M. Vummalaneni,
Andrew T. Morehead Jr,
Andrew L. Sargent and
Mitchell P. Croatt

Beilstein J. Org. Chem. 2017, 13, 384–392, doi:10.3762/bjoc.13.41

PDF

Graphical Abstract

Scheme 1: Prior and current decarboxylative couplings.

Jump to Scheme 1

Scheme 2: Esters examined in the decarboxylation reaction.

Jump to Scheme 2

Scheme 3: Possible mechanistic pathways.

Jump to Scheme 3

Figure 1: Calculated HOMO of transition state between E and F.

Jump to Figure 1

Album

Supp Info

Full Research Paper

Published 28 Feb 2017

Full text

Opportunities and challenges for direct C–H functionalization of piperazines

Zhishi Ye,
Kristen E. Gettys and
Mingji Dai

Beilstein J. Org. Chem. 2016, 12, 702–715, doi:10.3762/bjoc.12.70

PDF

Graphical Abstract

Figure 1: Selected piperazine-containing small-molecule pharmaceuticals.

Jump to Figure 1

Figure 2: Strategies for the synthesis of carbon-substituted piperazines.

Jump to Figure 2

Figure 3: The first α-lithiation of N-Boc-protected piperazines by van Maarseveen et al. in 2005 [37].

Jump to Figure 3

Figure 4: α-Lithiation of N-Boc-N’-tert-butyl piperazines by Coldham et al. in 2010 [38].

Jump to Figure 4

Figure 5: Diamine-free α-lithiation of N-Boc-piperazines by O’Brien, Campos, et al. in 2010 [40].

Jump to Figure 5

Figure 6: The first enantioselective α-lithiation of N-Boc-piperazines by McDermott et al. in 2008 [41].

Jump to Figure 6

Figure 7: Dynamic thermodynamic resolution of lithiated of N-Boc-piperazines by Coldham et al. in 2010 [38].

Jump to Figure 7

Figure 8: Enantioselective α-lithiation of N-Boc-N’-alkylpiperazines by O’Brien et al. in 2013 and 2016 [42,43].

Jump to Figure 8

Figure 9: Asymmetric α-functionalization of N-Boc-piperazines with Ph₂CO by O’Brien et al. in 2016 [43].

Jump to Figure 9

Figure 10: A “chiral auxiliary” strategy toward enantiopure α-functionalized piperazines by O’Brien et al. 201...

Jump to Figure 10

Figure 11: Installation of methyl group at the α-position of piperazines by O’Brien et al. 2016 [43].

Jump to Figure 11

Figure 12: α-Lithiation trapping of C-substituted N-Boc-piperazines by O’Brien et al. 2016 [43].

Jump to Figure 12

Figure 13: Rh-catalyzed reactions of N-(2-pyridinyl)piperazines by Murai et al. in 1997 [52].

Jump to Figure 13

Figure 14: Ta-catalyzed hydroaminoalkylation of piperazines by Schafer et al. in 2013 [55].

Jump to Figure 14

Figure 15: Photoredox catalysis for α-C–H functionalization of piperazines by MacMillan et al. in 2011 and 201...

Jump to Figure 15

Figure 16: Copper-catalyzed aerobic C–H oxidation of piperazines by Touré, Sames, et al. in 2013 [67].

Jump to Figure 16

Figure 17: Free radical approach by Undheim et al. in 1994 [68].

Jump to Figure 17

Figure 18: Anodic oxidation approach by Nyberg et al. in 1976 [70].

Jump to Figure 18

Album

Review

Published 13 Apr 2016

Full text

Other Beilstein-Institut Open Science Activities

/ Help / Support & Contact / Alerts / Privacy Policy / Terms & Conditions / Impressum